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Image-Guided Drug Delivery
Research Interests:
My current research focuses on the development and characterization of novel, biocompatible and biodegradable biomaterial based drug delivery systems with the help of noninvasive imaging techniques. Among our on going projects, we are utilizing a polymer Pluronic P85 that not only serves as a drug carrier but also serves as a chemo-sensitizer. With the accumulation of promising results from both of our in vitro and in vivo studies, I hope to look into cancer biology and further explore the mechanisms behind the sensitization effects of the polymer, which will eventually serve as my PHD thesis.
Selected Publications:
Krupka TM, Weinberg B, Ziats NP, Exner AA. Pluronic P85 improves therapeutic efficacy of intratumoral carboplatin. Pharmaceutical Research, submitted
Krupka TM, Weinberg B, Sinha A, Ziats NP, Haaga JR, Exner AA. Injectable polymer matrixes for local delivery of carboplatin to tumors following radiofrequency ablation. in preparation
Krupka TM, Smoke J, Exner AA.Pretreatment with amphiphilic surfactant improves the outcome of radiofrequency ablation. in preparation
Exner AA, Krupka TM, Scherrer K, Teets JM. Enhancement of carboplatin toxicity by Pluronic block copolymers. J Controlled Release, 106(1-2):188-197, 2005. |
