Magnetic Resonance Research:
Image-Guided Drug Delivery:
The primary focus of this research program is the development of a minimally invasive, image-guided combination treatment that utilizes radiofrequency (RF) ablation followed by site-specific delivery of chemotherapeutic drugs to the ablated area. Polymer matrixes are being formulated and refined to be used for delivery of chemotherapeutic drugs directly to solid tumors following the RF ablation procedure.
Molecular Imaging Research:
Multimodality Image Analysis:
The goals of this research program are to (1) provide efficient methods and procedures for mapping the properties of tissues in space and time, (2) integrate multiple information streams acquired from different imaging technologies into a single coherent picture, and (3) validate and interpret in vivo imaging data for biologic, physiologic, and pathologic interpretation.
Pharmacokinetic Modelling
Effective molecular imaging research depends on successful kinetic modeling of dynamic image data. The need for optimal experimental design and data analysis tools will grow as molecular imaging research expands. These techniques will be used in oncology (and other diseases) for diagnosis, staging, and monitoring response to therapy. The overall objective of this program is to fulfill currently unmet needs of quantitative analysis of image data.
Small Animal Imaging Center
The Imaging Research Center at Case Western Reserve University provides state of the art imaging research capabilities to faculty and employees of Case, University Hospitals of Cleveland, The Cleveland Clinic Foundation, MetroHealth Medical Center, and other academic and industrial instiitutions. The imaging center is commited to providing an efficient and cost-effective opportunity for collaborations for both clinical and preclinical research. Please feel free to contact me or other affiliated faculty/staff with any comments or questions regarding current and future imaging research applications.
