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Special interests:
Computer-Aided Diagnosis ,
Cardiovascular Research,
Intravascular MR research,
Multimodality Image Analysis
Selected links:
Department of Radiology
Department of Biomedical Engineering
Case Biomedical Imaging Laboratory
Olivier Salvado BME page
Publications for Olivier Salvado (PubMed)
View CV
Synopsis: Our research focuses on developing computer methods to help the analysis of medical images. In particular we investigate techniques to characterize atherosclerosis with Magnetic Resonance Imaging (MRI), including in vivo intravascular MRI. Several challenges need to be addressed that are common to almost all CAD methods: 1) accurate registration of multiple modalities and/or MR contrasts; 2) automatic tissue classification using prior information; 3) partial volume effect; 4) intensity inhomogeneity from the sensitivity of the MR receiver coils. In addition, intravascular MRI is complicated by the motion of the catheter and the artery wall being imaged, and the microcoils mounted at the tip of the catheters have very steep sensitivity profiles that challenge any intensity-based techniques. For the validation of our methods we use animal models, and a novel Cryo-Imaging system developed by Prof. David Wilson where ex vivo diseased vessels are frozen in block and serially cut while the block face is being imaged with bright field and fluorescence light. Using this technique we obtain 3D microscopic ground truth that can be matched to the MRI images. |
