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Research Interests:
My major research interest is in developing radiolabeled enzyme inhibitor and neuroreceptor ligand for measuring it’s expression in vivo for utilizing positron emission tomography (PET), This research area has a lot room for development, and there is a great prospects for synthesizing new imaging tracers that will be very useful in diagnose and treatment disease of the cancer and neuronal systems.
My fields of specialty are radiochemistry and organic synthesis, with emphasis on preparation of PET radiopharmaceuticals with the isotopes of 18F for the diagnoses and treatment. Conducting the basic chemical research for attaching various radioisotopes to biologically active molecules, such as receptors, enzyme, with the hope of developing new diagnostic agents for nuclear medicine. Research in these areas involve radiochemistry, organic synthesis, chemical and biochemical stability studies and a wide variety of analytical and chemical separation techniques.
Selected Publications:
• TIAN Hai-Bin YIN Duan-Zhi ZHANG Lan ZHANG Cun-Fu LI Jun-Ling ZHOU Wei WANG Yong-Xian, A potential dopamine D4 receptor imaging agent: radiosyntheses of 3-[4-(4-[18F]fluorobenzyl)]piperazin-1-yl}methyl-1Hpyrrolo[2,3-b]pyridine. Radiochim. Acta,91,241-245 (2003).
• TIAN Hai-Bin YIN Duan-Zhi ZHANG Lan WANG Li-Hua ZHANG Chun-Fu LI Jun-Ling ZHOU Wei WU Chun-Ying WANG Yong-Xian, Synthesis and Biological Evaluation of 3-{[4-(4-[18F]fluorophenyl)methyl] piperazin-1-yl}-methyl-1H-pyrrolo[2,3-b]pyridine for in Vivo Studies of Dopamine D4 receptor, Journal of Radioanalytical and Nuclear Chemistry, 262(2): 383-389, 2004
• TIAN Hai-Bin, YIN Duan-Zhi, ZHANG Lan, WANG Li-Hua, ZHANG Chun-Fu, WANG Ming-Wei, WU Chun-Ying, WANG Yong-Xian. Dopamine D4 Receptor Antagonist 3-(4-[18F]fluorobenzyl)-8-methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one: Radiosynthes and In Vivo Characterization in Rats. Applied Radiation and Isotopes, 63(3), 333-342, 2005
• Haibin Tian, Zhenghong Lee.Synthesis of 18F-labelled Cyclooxygenase-2 (COX-2) Inhibitor as a Potential PET Imaging Agent. J.Labelled .Compd. Radiopharm, (submitted).
• TIAN Hai-Bin YIN Duan-Zhi ZHANG Lan WANG Li-Hua ZHANG Chun-Fu WU Chun-Ying WANG Yong-Xian , Dopamine D4 Receptor Antagonist 3-(4-[18F]fluorobenzyl)-8-methoxy-1,2,3,4-tetrahydrochromeno[3,4-c]pyridin-5-one: Radiosynthes and In Vivo Characterization in Rats.(Paper Number:PO9-02). 15th International Symposium on Radiopharmaceutical Chemistry, 10 - 14 August 2003 , Sydney, Australia.
• Haibin Tian, Ronald M. Baldwin, Rebecca Vogel, Louis Amici, Gilles Tamagnan, Radiosynthesis of 3-(3-[18F] Fluoropropoxy)-4-(benzyloxy)-N-[(1-(dimethylamino)cyclopentyl)methyl]-5-methoxybenzamide, a PET Radiotracer for the Glycine Transporters GlyT-2. Fifth international Symposium on Radiohalogens. September 11-15,2004. Whistler, BC Canada.
• TIAN Hai-bin, ZHANG Lan, ZHANG Chun-fu, LI Jun-ling, YIN Duan-Zhi, Progress of study on the Dopamine D4 Receptor Imaging Agen. Asian Journal of Nuclear Medicine Vol 1(3),2002:192-195.
• TIAN Hai-bin, YIN Duan-Zhi, ZHANG Lan , ZHANG Chun-fu, LI jun-ling, WANG Li-Hua, Zhou wei, WANG Yong-Xian, Guo Zhi-li, 7-Azaindole Derivative -Syntheses of a potential dopamine D4 Receptor Imaging Agent. Chinese Joural of Pharmacentical Chemistry,Vol 12(4),2002:214-218.
• TIAN Hai-bin, YIN Duan-Zhi, ZHANG Lan , ZHANG Chun-fu, LI jun-ling, Zhou wei, WANG Yong-Xian, Radiosyntheses of 3-[4-(4-[18F]fluorobenzyl)]piperazin-1-yl}methyl-1Hpyrrolo[2,3-b]pyridine. Nuclear Science and Technology. 26(8):46-48, 2003.
• TIAN Hai-bin,Yao Yan, SONG Peng-seng, Studies of Activity Coefficients and Combination Equilibrium for LiCl-Li2B4O7-H2O System at 298.15 K, Chemical Research and Application (china), 12(4):403-408, 2000.
• TIAN Hai-bin,Yao Yan, SONG Peng-seng, LONG Guang-ming, WANG Luying, Studies of Activity Coefficients and Dissociation Equilibrium for LiCl-Li2B4O7-H2O System at 298.15 K. Journal of Salt Lake Research (china), 8(4):29-36, 2000.
• Li Junling, Wang Yongxian, Tian Haibin, Zhang Xiuli, Lin Yingwu, Yin Duanzhi, An improved radiochemical synthesis of N-succinimidyl 4-18F-(fluoromethyl)benzoate and the labeling of IgG, Journal of Radioanalytical and Nuclear Chemistry. 254(2): 415-419, 2002.
• Zhang Chunfu, Wang Yongxian, Tian Haibin et al., "Preparation of iodine-125 seed. I. iodination of the silver rod", Journal of Radioanalytical and Nuclear Chemistry, 252(1):161-163, 2002.
• Zhang Chunfu, Wang Yongxian, Tian Haibin et al., "Preparation of 103 Pd seed. II. molecular plating of 103 Pd onto copper rod", Journal of Radioanalytical and Nuclear chemistry,253(2): 313-316, 2002.
• Zhang Chunfu, Wang Yongxian, Tian Haibin et al., "Molecular plating of 103Pd onto silver rod", Applied Radiation and Isotopes, 57:309-311, 2002.
• Tian, Haibin; Yin, Duanzhi; Wang, Yongxian. Preparation of [18F]Fluoro-labeled pyridine derivative as contrast medium for dopamine D4 receptor. Patent Number: CN1467208 Faming Zhuanli Shenqing Gongkai Shuomingshu (2004).
• Yin, Duanzhi; Tian, Haibin; Wang, Yongxian. Process for preparation of 18F labeled 8-methoxy-3-(4-fluorobenzyl)-1,2,3,4-tetrahydrobenzopyran[3,4-C]pyridine-5-one. Patent Number: CN1519242 Faming Zhuanli Shenqing Gongkai Shuomingshu (2004 ) |
